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KMID : 0939920090410040218
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대한암학회지
2009 Volume.41 No. 4 p.218 ~ p.223
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No Association of Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-C Expression with Survival in Patients with Gastric Cancer
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Lee Soo-Jung
Kim Jong-Gwang
Sohn Sang-Kyun
Chae Yee-Soo
Moon Joon-Ho
Kim Shi-Nae
Bae Han-Ik
Chung Ho-Young
Yu Wan-Sik
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Abstract
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Purpose :Although the vascular endothelial growth factor (VEGF) superfamily has been identified to critically influence tumor-related angiogenesis, the prognostic significance of a VEGF expression in gastric cancer is still controversial. Accordingly, the present study analyzed the VEGF-A and VEGF-C expressions and their impact on the prognosis of patients with gastric cancer.
Materials and Methods :Three hundred seventy-five consecutive patients who underwent surgical resection for gastric adenocarcinoma with a curative intent were enrolled in the present study. Immunohistochemical staining for VEGF-A and VEGF-C was performed using the formalin fixed, paraffin embedded tumor tissues.
Results :Positive VEGF-A and VEGF-C expressions were observed in 337 (90.1%) and 278 (74.9%) cases, respectively. The survival analysis showed that the expression of VEGF-A and VEGF-C had no effect on the OS and DFS. On the multivariate analysis that included age, gender and the TNM stage, no significant association between the grade of the VEGF-A or VEGF-C expression and survival was observed.
Conclusion :The current study suggests that the tissue expression of VEGF-A or VEGF-C alone is not an independent prognostic marker for patients with surgically resected gastric adenocarcinoma.
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KEYWORD
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Stomach neoplasms, VEGF-A, Prognosis.
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